Professor, Department of Pharmaceutical Chemistry at UCSF
An overarching interest is to bring chemical reagents to biology, using a combination of computational simulation and experiment. Using a protein-centric approach, we search for new ligands that complement protein structures. Using a ligand-centric approach, we try to find new targets for known drugs. A particular focus is the discovery of reagents to modulate G-Protein Coupled Receptors. Two crazy goals for the next five years are predicting one ligand for every accessible protein target, and for every drug predicting one new target to which it binds.